Citronellal ameliorates doxorubicin‐induced hepatotoxicity via antioxidative stress, antiapoptosis, and proangiogenesis in rats
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منابع مشابه
Curcumin Ameliorates Sertraline-mediated Testicular Toxicity in Rats via Inhibition of Oxidative Stress
Background: Sertraline is prescribed mainly for the treatment of patients with depression. However, this drug is known to have toxic effects on the male germ cells. Therefore, this study was designed to examine the ameliorative effects of curcumin on the sertraline-induced male reproductive toxicity. Methods: Thirty-two male Wistar rats were randomly divided into four groups of eight each. The...
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Prolonged inflammation and oxidative stress are emerging as key causes of pathological wound healing and the development of liver fibrosis. We have investigated the effects of recombinant human kallistatin, produced in Pichia. pastoris, on preventing carbon tetrachloride (CCl4)-induced liver fibrosis in rats. Daily administration of kallistatin prevented development of CCl4-induced liver fibros...
متن کاملAstragaloside IV ameliorates renal fibrosis via the inhibition of mitogen-activated protein kinases and antiapoptosis in vivo and in vitro.
Apoptosis of renal tubular cells plays a crucial role in renal fibrosis. Astragaloside IV (AS-IV), a compound extracted from Radix Astragali, has been shown to inhibit renal tubular cell apoptosis induced by high glucose, but its role in preventing chronic renal fibrosis as well as the underlying molecular mechanisms involved still remain obscure. In this study, human kidney tubular epithelial ...
متن کاملCarthamus tinctorius L. ameliorates brain injury followed by cerebral ischemia-reperfusion in rats by antioxidative and anti-inflammatory mechanisms
Objective(s): Carthamus tinctorius L. (CT) or saffloweris widely used in traditional Chinese medicine. This study investigated the effects of CT extract (CTE) on ischemia–reperfusion (I/R) brain injury and elucidated the underlying mechanism. Materials and Methods: The I/R model was conducted by occlusion of both common carotid arteries and right middle cerebral artery for 90 min followed by 24...
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ژورنال
عنوان ژورنال: Journal of Biochemical and Molecular Toxicology
سال: 2020
ISSN: 1095-6670,1099-0461
DOI: 10.1002/jbt.22639